distribution of i-125-igg in normal and induced inflammation in mice [persian]

antibodies are a diverse class of glycoproteins that specially bind with antigen and elicit a number of secondary responses in vivo. most of the applications of antibodies in basic research diagnosis and immunotherapy rely on labeling of the antibody with radiopharmaceuticals. radiolabeled antibodies are a new class of imaging agents for the detection of sites of disease. true biodistribution of igg has a great importance to develope antibody conjugates for delivering radionuclides or drugs to desired sites. in this study, igg was iodinated by chloramine-t method. injecting turpentine in the left thigh of mice induced inflammation. distribution of i-125-igg in normal and induced inflammation mice was assessed. results showed the accumulation of i-125-igg in inflammed muscle was more than normal muscle.